The significant of other people with Asperger's are more prone to major depression than the general population because people with Asperger's often have trouble showing affection or have little desire to show affection, and can be very literal and hard to communicate with in an emotional way. It is helpful for those involved with someone with Asperger's to read as much as they can about Asperger's syndrome, obsessive-compulsive disorder, hyperlexia and other comorbid disorders. It also helps to visit support groups' websites on the Web and talk with others who are involved with people with Asperger's. A significant other will often be much less angry or depressed if he or she understands that the Asperger's symptoms are not intentionally directed, but are part of a neurodevelopmental disorder.

That when someone does not spontaneously show affection, it does not necessarily mean that he or she does not feel it. Thus, the significant other will come to feel less rejected and be more understanding. Light will be shed on the nature of the misunderstandings. They may figure out ways to work around the problems; for example, by being more explicit about their needs. For instance, when describing emotions, it can be helpful to be direct and to avoid vague terms like "upset" when the emotion being described is "anger". Another suggestion could be to lay out in clear language what the problem is and to ask the partner with Asperger's to describe what emotions are being felt or ask why a certain emotion was being felt.

A gift and a curse:
Recently, some researchers have speculated that many well-known people including Andy Warhol, Andy Kaufman, Craig Nicholls, Rainer Werner Fassbinder, Glenn Gould, Gary Numan, Erik Satie, Nikola Tesla, Albert Einstein, Isaac Newton, Friedrich Nietzsche, Theodore Kaczynski, William James Sidis, Bobby Fischer, Steven Spielberg and Bill Gates have or had AS, as they showed some Asperger's related tendencies, such as intense interest in one subject, and social problems. Such diagnoses remain controversial, however (cf. BBC News, Einstein and Newton "had autism", 30 April 2003), and some more so than others, as most scholars seem to agree that Satie suffered at least from some form of autism.

The obvious social contributions of such individuals has led to a shift in the perception of Asperger's and autism away from the simple view of a disease needing to be cured towards a more complex view of a syndrome with advantages and disadvantages. There is a semi-jocular theory within science fiction fandom, for example, which argues that many of the distinctive traits of that subculture may be explained by the speculation that a significant portion thereof is composed of people with Asperger's. A Wired Magazine article called The Geek Syndrome suggested that Asperger's syndrome is more common in the Silicon Valley, a haven for computer scientists and mathematicians.

It created an enduring myth popularized in the media and self-help books that "Geek Syndrome" equals Asperger's syndrome, and precipitated a rash of self-diagnoses. Though these conditions do share traits, there is a consensus that most geeks are arguably "variant normal" and do not exhibit autistic-spectrum behaviors. "Geeks" may exhibit an extreme professional or casual interest in computers, science, engineering and related fields, and may be introverted; however, they do not suffer from impairments per se. This does not imply that there is no overlap between "geeks" and Asperger's patients, but it should be noted that self-diagnosis is a dangerous practice, and one prone to error.

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